Expression of Ki-67 antigen in various histological types of BASAL CELL CARCINOMA

Background : Basal cell carcinoma (BCC) is the most commonest malignant tumor of skin especially fair-skinned individuals makes up roughly 70–80% all tumors. In certainty, this malignancy had a variety many sub-types, through distinct histo-morphological appearance and biological function. Unlike other tumors, usually has an affirmative clinical course, developing slowly just locally. Antibodies against “Ki-67 antigen” or proliferating Cell nuclear antigen (PCNA) are typically used in immunohistochemistry to detect proliferative activity (growth fraction) malignancies. Aim study This aims examine cells' status utilizing analysis “Ki-67” biopsy specimens different sub-type BCCs. Material methods A Case series enrolling 35 biopsies sampled from retrospectively selected cases cutaneous BCCs were registered research. Results Thirty five (31 Primary, 4 Recurrent)of histological types patients (11 male, 24 female) included. The patient’s age ranged 36 75 years (with mean 59.2 year) .In results showed that site involvement was face 71.4% , there significant association between size Ki67 level grade, reported non-significant subtype level. Discussion data wide range ki67 (2 70%) among various growth basal carcinoma, higher index indicate more potential lower less aggressive tumor. So proliferation which been BCC illuminate spectrum